Preparation of (9Z, 11Z) - Vitamin A
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Add time:07/14/2019 Source:sciencedirect.com
Starting from (7E,9Z)-C15-aldehyde 4, the syntheses of (9Z, 11Z)-vitamin A acetate and palmitate are reported. The construction strategy is based on treatment of 4 with Zn-PPh3/CBr4, addition of acetaldehyde followed by a Wittig-Horner reaction to give the (9Z, 11Z)-C20-nitrile 7 which was reduced with DIBAH to the corresponding aldehyde 8 and then to the title compound 1. The thermal instability of 1 is discussed.
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