1,3-Heterazolidines-2-heterounsaturated compounds derived from ephedrines

Add time:07/28/2019    Source:sciencedirect.com

Herein, a direct and easy method for preparing 2-oxo-, 2-thione- or 2-imine-1,3-heterazolidines derived from ephedrines and norephedrines are reported. The method is based on solvent free heating of ephedrines with oxocyanate or thiocyanate salts (180–200 °C). In the reactions with potassium oxocyanate in refluxing ethanol, it was possible to isolate ureidic derivatives. The structure and stereochemistry of the compounds were determined by 1H, 13C NMR, IR spectroscopies and mass spectrometry. Ureidic derivatives, cis-1,5-dimethyl-4-phenyl-imidazolidine-2-thione and trans-4-methyl-5-phenyl-thiazolidine-2-one are new compounds. Ephedrineurea, cis-1,5-dimethyl-4-phenyl-imidazolidine-2-thione and trans-4-methyl-5-phenyl-thiazolidine-2-one were also studied by X-ray diffraction.

We also recommend Trading Suppliers and Manufacturers of 1-Methyl-2-imidazolidinethione (cas 13431-10-2). Pls Click Website Link as below: cas 13431-10-2 suppliers

Prev:Synthesis, structural characterization, formation constants and in vitro cytotoxicity of phenanthroline and imidazolidine-2-thione copper(II) complexes
Next:Unexpected products from the reaction of different compounds with hydrazine hydrate or aryl thiosemicarbazides)