Inhibition of gramicidin S synthetase 2 by L-phenylalanine chloromethyl ketone
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Add time:07/29/2019 Source:sciencedirect.com
The inhibition of the gramicidin S-biosynthesis and the thioester formation activities of the multienzyme GS 2 by L-Phe-CMK, a substrate analogue of L-phenylalanine, were investigated. L-Phe-CMK inhibits irreversibly the activation of proline, valine, ornithine and leucine with about the same velocity and shows no specificity for hydrophobic amino acid binding sites, as could be expected. The gramicidin S-biosynthesis is inhibited about four times more rapidly than the thioester formation. Prevention of inhibition by the substrates opens the possibility of specific blocking of one or more active sites of the enzyme.
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