Effect of the disintegrin eristostatin (cas 132051-67-3) on melanoma–natural killer cell interactions

Add time:07/27/2019    Source:sciencedirect.com

Malignant melanoma is difficult to treat due to its resistance to chemotherapeutic regimens. Discovery of new pharmaceuticals with inhibitory potential can be helpful in the development of novel treatments. The snake venom disintegrin eristostatin (cas 132051-67-3), from the viper Eristicophis macmahoni, caused immunodeficient mice to be significantly protected from development of lung colonization when melanoma cells and the disintegrin were co-injected in vivo into the lateral tail vein compared to vehicle controls. Cytotoxicity assays suggested that eristostatin makes the melanoma cells a better target for lysis by human natural killer cells. Direct binding assays using atomic force microscopy showed eristostatin does specifically bind the surface of the six melanoma cell lines tested. Eristostatin binding was partially inhibited by the addition of soluble RGDS peptide, suggesting an integrin as one likely, but not the sole, binding partner. Studies done with melanoma cells on a culture dish and natural killer cells attached to a cantilever tip in atomic force microscopy showed four major populations of interactions which exhibited altered frequency and unbinding strength in the presence of eristostatin.

We also recommend Trading Suppliers and Manufacturers of eristostatin (cas 132051-67-3). Pls Click Website Link as below: cas 132051-67-3 suppliers

Prev:Association rules mining in R for product performance management in industry 4.0
Next:Inhibition of melanoma cell motility by the snake venom disintegrin eristostatin (cas 132051-67-3))