Design, synthesis, and optical resolution of a novel non-natural chiral auxiliary, 1-(2,5-dimethoxyphenyl)ethylamine. Application to diastereoselective alkylation of aldimines

Add time:07/27/2019    Source:sciencedirect.com

A chiral amine, 1-(2,5-dimethoxyphenyl)ethylamine, was found to be an effective chiral auxiliary for the diastereoselective alkylation of its aldimines with alkylmetals. The 1-(2,5-dimethoxyphenyl)ethyl group of the chiral auxiliary could be removed by the acetylation and then oxidation of the resultant alkylated product, accompanying an amino-transfer from the chiral auxiliary to the final product. Racemic 1-(2,5-dimethoxyphenyl)ethylamine could be easily synthesized from 1,4-dimethoxybenzene and resolved by the diastereomeric salt formation with mandelic acid to give both enantiomers in pure forms.

We also recommend Trading Suppliers and Manufacturers of N-ETHYL-2-(3,4-DIMETHOXYPHENYL)ETHYLAMINE (cas 112933-49-0). Pls Click Website Link as below: cas 112933-49-0 suppliers

Prev:Synthesis and evaluation of antipsychotic activity of 11-(4′-(N-aryl carboxamido/N-aryl-α-phenyl-acetamido)-piperazinyl)-dibenz[b,f][1,4]-oxazepine derivatives
Next:Function and molecular basis of action of vasopressin 4—8 and its analogues in rat brain)