Conformation and pairing properties of the N-terminal fragments of trichorzianine and alamethicin: a theoretical study

Add time:07/29/2019    Source:sciencedirect.com

Energy optimizations are carried out on the N-terminal fragment of trichorzianine in comparison to that of alamethicin. The results indicate that the helical character of the (Ac…Pro13) sequence of trichorzianine (TA IIIc) is essentially alpha with a bend in the helix axis in the end proline region, a structure comparable to the optimal α-helical structure of the corresponding segment (Ac…Pro14) of alamethicin AI. However, two weak n → n + 3 interactions coexist in trichorzianine with the α-helical n → n + 4 hydrogen bonds. The possible role of the glutamine side-chains in pairing such segments together is considered.

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