The effect of the LEUCOPYROKININ (cas 104052-00-8) analogue: [2-8]-LEUCOPYROKININ (cas 104052-00-8) on central opioid receptors in rats

Add time:07/28/2019    Source:sciencedirect.com

The antinociceptive effect of intracerebroventricular injections of [2–8]-LEUCOPYROKININ (cas 104052-00-8) (LPK), a truncated leucopyrokinin analogue, was determined in rats, by means of a tail immersion test. We found a significant antinociceptive effect of three i.c.v. doses of [2–8]-LPK: 1, 5 and 10 nmol. Pre-treating animals with naloxone hydrochloride (1 mg/kg i.p.) completely blocked the effect of two high doses of [2–8]-LPK. To determine the sub-types of opioid receptors involved in [2–8]-leucopyrokinin-induced analgesia we injected specific blockers of μ-, δ- and κ-receptors namely, β-funaltrexamine hydrochloride, naltrindole hydrochloride and nor-binaltorphimine dihydrochloride, respectively, prior to [2–8]-leucopyrokinin at equimolar doses. We conclude that the antinociceptive effect of [2–8]-leucopyrokinin is mediated mainly by central μ- and δ-opioid receptors.

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