The preparation and alkylation of a butanedione-derived chiral glycine equivalent and its use for the synthesis of α-amino acids and α,α-disubstituted amino acids

Add time:08/01/2019    Source:sciencedirect.com

A benzyloxycarbonyl protected glycine equivalent 2 has been prepared in enantiopure form and has been used in the synthesis of both α-substituted amino acids and α,α-disubstituted amino acids. The process involved deprotonation to form the corresponding enolates which underwent stereoselective alkylation with various electrophiles and upon hydrolysis gave the corresponding amino acid derivatives as enantiomerically pure products.

We also recommend Trading Suppliers and Manufacturers of 2-broMo-3-oxo-3-phenylpropanoic acid (cas 132089-31-7). Pls Click Website Link as below: cas 132089-31-7 suppliers

Prev:Stereoselective synthesis of (E)-β-arylvinyl bromides by microwave-induced reaction of anti-3-aryl-2,3-dibromopropanoic acids using an AgOAc–AcOH system
Next:Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics)