Determination of ebselen-sensitive reactive oxygen metabolites (ebROM) in human serum based upon N,N′-diethyl-1,4-phenylenediamine oxidation

Add time:07/11/2019    Source:sciencedirect.com

BackgroundOxidative stress occurs through free radical- and non-radical-mediated oxidative mechanisms, but these are poorly discriminated by most assays. A convenient assay for oxidants in human serum is based upon the Fe2+-dependent decomposition of peroxides to oxidize N,N′-diethyl-1,4-phenylenediamine (DEPPD) to a stable radical cation which can be measured spectrophotometrically.

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