Preparation and use of novel (S)-β-chlorodifluoromethyl-β-propiolactone as a chiral fluorinated building block
-
Add time:08/05/2019 Source:sciencedirect.com
Novel chiral fluorinated building block, (S)β-chlorodifluoromethyl-β-propiolactone with up to >99% ee was prepared using the Lewis acid catalyzed [2+2]cycloaddition of ketene with chlorodifluoroacetaldehyde followed by enzymatic resolution with a lipase. The lactone thus obtained readily underwent the Friedel-Crafts type acylation with aromatic compounds in the presence of a Lewis acid to afford the corresponding chiral β-hydroxy aryl ketones in good yields.
We also recommend Trading Suppliers and Manufacturers of 2-(Chlorodifluoromethyl)-1,1,1-trifluoro-2-pentanol (cas 10315-77-2). Pls Click Website Link as below: cas 10315-77-2 suppliers
Prev:The role of halogen C–X1⋯X2–C contact on the preferred conformation of 2-perhalomethylchromones in solid state
Next:A convenient synthesis of 2,2-difluoro enol silyl ethers from chlorodifluoromethyl ketones) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- A convenient synthesis of 2,2-difluoro enol silyl ethers from chlorodifluoromethyl ketones08/06/2019
- The role of halogen C–X1⋯X2–C contact on the preferred conformation of 2-perhalomethylchromones in solid state08/04/2019
- Reactions of chlorodifluoromethyl radicals08/03/2019
- Reactions of 3-chloropentafluoropropene-1,2-oxide with bifunctional nucleophiles: a new route to chlorodifluoromethyl-substituted heterocycles08/02/2019
- Reactions of (chlorodifluoromethyl)benzene and (chlorodifluoromethoxy)benzene with nucleophilic reagents08/01/2019
- Chlorodifluoromethyl-substituted monosaccharide derivatives—radical activation of the carbon–chlorine-bond07/31/2019
- Synthesis of lactones with a chlorodifluoromethyl group07/30/2019
- Efficient synthesis of p-bis-(chlorodifluoromethyl)benzene07/29/2019
- Chlorodifluoromethyl aryl ketones and sulfones as difluorocarbene reagents: The substituent effect07/28/2019
