circNrxn2 promoted WAT browning via sponging miR-103 to relieve its inhibition of FGF10 in HFD mice

Add time:07/29/2019    Source:sciencedirect.com

The accumulation of excess white adipose tissue (WAT) has harmful consequences on metabolic health. WAT browning confers beneficial effects on adiposity, insulin resistance and hyperlipidaemia. In this study, it was found out that circNrxn2 sponged miR-103, and enhanced FGF10 levels in HFD mice WAT. We discovered that circNrxn2 promoted WAT browning and mitochondria functions. Furthermore, circNrxn2 also increased M2 macrophages polarization in HFD mice adipose tissue and PPARγ signaling pathway participated in these biological processes. Moreover, eliminating adipose tissue macrophages (ATMs) by clodronate crippled circNrxn2 promoted WAT browning, and the simulation co-culture of macrophages and adipocytes results suggested that circNrxn2 promoted WAT browning through increasing M2 macrophages polarization. Our finding revealed that circNrxn2 acted as an endogenous miR-103 sponge, blocked miR-103 effects and relieved its inhibition on FGF10 expression to promote WAT browning through increasing M2 macrophages polarization. This study provides a good therapeutic strategy for treating obesity and improving obesity-related metabolic disorders.

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