Micelle enhanced and native spectrofluorimetric methods for determination of SERTINDOLE (cas 106516-24-9) using sodium dodecyl sulfate as sensitizing agent

Add time:07/28/2019    Source:sciencedirect.com

Two stability indicating spectrofluorimetric methods were developed and validated for the determination of SERTINDOLE (cas 106516-24-9) (SER) in the presence of its acid and oxidative degradates at λex 257 nm and λem 335 nm. Method A was based on measuring the native fluorescence of SER using isopropanol as solvent. Method B was based on the enhancement of native fluorescence of SER quenched in aqueous media by using micellar microenvironment created by sodium dodecyl sulfate (SDS) anionic micelles using Britton Robinson Buffer (BRB) pH 3.29 as solvent. Different factors affecting fluorescence intensity; both native and enhanced, were carefully studied to reach the optimum conditions of measurements. The proposed spectrofluorimetric methods were validated in accordance with ICH guidelines and were successfully applied for the determination of SER in bulk powder and pharmaceutical preparation with high sensitivity and stability indicating power. They were also statistically compared to the manufacturer methods with no significant difference in performance.

We also recommend Trading Suppliers and Manufacturers of SERTINDOLE (cas 106516-24-9). Pls Click Website Link as below: cas 106516-24-9 suppliers

Prev:Syntheses of the antibiotic alkaloids renierone, mimocin, renierol, renierol acetate, renierol propionate, and 7-methoxy-1,6-dimethylisoquinoline-5,8-dione
Next:Anodic dissolution behavior of zirconium in Bun4NBr-containing isopropanol solution)