Synthesis of (αR, 6R or 6S)-N-(α-methylbenzyl)-6-difluoromethyl-4- hydroxy-4- (4-chlorophenyl) piperidines

Add time:07/12/2019    Source:sciencedirect.com

Diasteroeselective synthesis of (αR, 6R or 6S)-N-(α-methylbenzyl)-6-difluoromethyl-4-hydroxy-4-(4-chlorophenyl)piperidines, which were produced from the reaction of R, 6R)- or (αR, 6S)-N-(α-methylbenzyl)-6-difluoromethyl-4-piperidone and 4-chlorophenyllithium, is described.

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