Fibril-forming model synthetic peptides containing 3-Aminophenylacetic acid (cas 14338-36-4)

Add time:07/30/2019    Source:sciencedirect.com

The FT-IR, 1H NMR, electrospray mass spectrometry studies of several dipeptides containing 3-APA (3-aminophenylacetic acid) and Aib/Val/Pro, revealed that all peptides share a common structural feature, an extended backbone conformation and they form the intermolecular hydrogen bonded supramolecular β-sheet structure in the solid state. The SEM images of all peptides exhibit amyloid-like fibrils, reminiscent of many neurodegenerative diseases like Alzheimer's, Prion-protein diseases.

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