Microbial synthesis of (+) and (−) methyl 4-chloro-4,4-difluoro-3-hydroxybutanoate

Add time:07/29/2019    Source:sciencedirect.com

Microbial reduction with baker's yeast or Aspergillus niger of methyl 4-chloro-4,4-difluoro-3-oxobutanoate 1 afforded the optically active methyl (−)-4-chloro-4,4-difluoro-3-hydroxybutanoate 2. When yeast reduction was carried out in the presence of allyl bromide the optically active methyl (+)-4-chloro-4,4-difluoro-3-hydroxybutanoate 2 was obtained.

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