Synthesis of an immunomodulator (+)-conagenin (cas 134381-30-9) and its analogs
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Add time:07/29/2019 Source:sciencedirect.com
Stereoselective synthesis of an immunomodulator (+)-conagenin was achieved. Both amine and carboxylic acid moieties were prepared from commercially available optically active methyl 3-hydroxy-2-methylpropanoate using dirhodium(II)-catalyzed C–H amination and chelation-controlled reductions as key steps. In addition, demethyl analogs of conagenin were synthesized using similar procedures.
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