Structure-activity studies of N-cyano-3-pyridinecarboxamidines and their amide and thioamide congeners

Add time:07/29/2019    Source:sciencedirect.com

The vasorelaxant and cardiac effects of N-cyano-3-pyridinecarboxamidine A were compared with those of their amide (B) or thioamide (C) congener. Cyanoamidine was the most potent skeleton in comparison with amide or thioamide, and the activities of these three compounds are more selective for vascular smooth muscle than myocardium.

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