UHPLC-Q-TOF-MS/MS method based on four-step strategy for metabolites of HINOKIFLAVONE (cas 19202-36-9) in vivo and in vitro
-
Add time:07/29/2019 Source:sciencedirect.com
HINOKIFLAVONE (cas 19202-36-9) (HF), belonging to biflavonoids, possesses excellent pharmacological activities, including anti-inflammatory, antioxidant and antitumor activity. Nevertheless, its metabolism in vivo (rats) and in vitro (rat liver microsomes and intestinal flora) is presently not characterized. In this study, ultra-high-performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) based on four-step strategy was a rapid method for the detection of HF metabolites. A total of 41 metabolites in vivo, 49 metabolites in vitro were characterized. It also verified that intestinal tract exceeds the liver in the biotransformation of HF. More significant, the main metabolic pathways for HF were mainly bio-transformed to various mono-flavone resulting from the rupture of connective CO bonds, which exhibited a large distinction with other biflavones. Noteworthily, glutamine conjugation and glycine conjugation were considered as unique metabolic pathways of HF. The information obtained from this study contributes to better understanding of pharmacological mechanism of HF.
We also recommend Trading Suppliers and Manufacturers of HINOKIFLAVONE (cas 19202-36-9). Pls Click Website Link as below: cas 19202-36-9 suppliers
Prev:Experimental and density functional theory and ab initio Hartree-Fock study on the vibrational spectra of 5-chloro-6-(4-chlorobenzoyl)-2-benzothiazolinone molecule
Next:HINOKIFLAVONE (cas 19202-36-9) induces apoptosis in melanoma cells through the ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- 13C NMR studies of some naturally occurring amentoflavone and HINOKIFLAVONE (cas 19202-36-9) biflavonoids08/01/2019
- Evaluation of the hepatoprotective effect of combination between HINOKIFLAVONE (cas 19202-36-9) and Glycyrrhizin against CCl4 induced toxicity in rats07/31/2019
- HINOKIFLAVONE (cas 19202-36-9) induces apoptosis in melanoma cells through the ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion07/30/2019