Metabolic activation of hexamethylmelamine and pentamethylmelamine (cas 16268-62-5) by liver microsomal preparations

Add time:07/30/2019    Source:sciencedirect.com

Incubation of [14C]-ring labeled hexamethylmelamine and pentamethylmelamine (cas 16268-62-5) with rat and mouse liver microsomal preparations results in metabolic activation of both drugs as measured by covalent binding of radiolabel to acid-precipitable microsomal macromolecules. Covalent binding is dependent on viable microsomes, NADPH, and molecular oxygen. Binding of HMM (280 pmol/mg protein/15 min) was approximately 5 times greater than that observed for PMM (60 pmol/mg protein/15 min), and represents 0.22% of incubated material. Similar results were found with [14C]-methyl labeled substrates. Pretreatment with phenobarbital increased covalent binding while addition of SKF 525-A, addition of glutathione, or incubation in an 80% carbon monoxide atmosphere reduced covalent binding.

We also recommend Trading Suppliers and Manufacturers of pentamethylmelamine (cas 16268-62-5). Pls Click Website Link as below: cas 16268-62-5 suppliers

Prev:Central side effects of pentamethylmelamine (cas 16268-62-5): Biochemical and behavioural studies
Next:Viscosities and deviations in viscosity of tert-butanol with n-butylamine, di-n-butylamine and tri-n-butylamine)