A synthetic procedure for the preparation of oligonucleotides without using ammonia and its application for the synthesis of oligonucleotides containing 0-4-alkyl thymidines.
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Add time:08/03/2019 Source:sciencedirect.com
The preparation of 5′-O-dimethoxytrityl (DMT) and p-nitrophenylethyl (NPEOC, NPE) protected nucleosides linked to 4-(2-hydroxyethyl)-3-nitrobenzoic acid derivatives is described. These products attached to controlled-pore glass supports and together with DMT and NPE-protected nucleoside cyanoethyl phosphoramidites allows for the first time the preparation of short oligonucleotides containing the ammonia sensitive mutagenic bases 0-4-propyl and 0-4-butyl thymidines.
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