Synthesis and biological evaluation of novel symmetry bis-enediynes
-
Add time:08/05/2019 Source:sciencedirect.com
A series of acyclic symmetry bis-enediynes have been synthesized successfully and their bioactivities were evaluated. Among them, 1,6-bis(4-((2-(pyridin-2-ylethynyl)phenyl)ethynyl)phenoxy)hexane 8g showed good inhibition activity against the CCRF-CEM (GI50 = 0.04 μM) and HL-60 (GI50 = 0.09 μM) cell lines of human leukemia. The cell cycle analysis shows that compound 8g arrests cell cycle via inhibiting Cyclin A and Cyclin B expressions in low concentration and induces a significant apoptosis progress in high concentration.
We also recommend Trading Suppliers and Manufacturers of Bis(4-cyanophenyl)methanol (cas 134521-16-7). Pls Click Website Link as below: cas 134521-16-7 suppliers
Prev:Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines
Next:Synthesis, characterization and crystal structures of HgII complexes with asymmetric ortho-functionalized 1,3-bis(aryl)triazenide ligands) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Synthesis, characterization and crystal structures of HgII complexes with asymmetric ortho-functionalized 1,3-bis(aryl)triazenide ligands08/06/2019
- Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines08/04/2019
- A novel bis(dihydroxypropyl) viologen-based all-in-one electrochromic device with high cycling stability and coloration efficiency08/03/2019
- Twisted internal charge transfer (TICT) effect in bis(4-cyanophenyl)piperazine, a pseudo-dimer of dimethylaminobenzonitrile: a comparative study08/02/2019
- New pentamethylene-bridged bis-imidazolium dication ligands and its palladium(II) complexes: Synthesis, characterization, and catalysis08/01/2019
- Catalytic, biological and DNA interaction studies of 3-(4-cyanophenyl)-2-methylacrylate organotin(IV) carboxylates derivatives: Synthesis, spectroscopic characterization and X-ray structures07/31/2019
- Rhodium(III) pentamethyl cyclopentadienyl complexes incorporating 1-(4-cyanophenyl)-imidazole: role of solvent in ligand substitution reactions07/30/2019
