Simvastatin ameliorates total liver ischemia/reperfusion injury via KLF2-mediated mechanism in rats
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Add time:08/03/2019 Source:sciencedirect.com
SummaryObjectiveThe total hepatic ischemia/reperfusion injury (IRI) involves the fact that both liver and gut are subjected to warm ischemia, which is a complex unavoidable process encountered during liver transplantation and a serious threat to graft outcome. The ways to improve hepatic IRI are currently limited. The aim of the present study was to explore the protective effect of simvastatin on total hepatic IRI and examine the underlying mechanisms.
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