A platform for designing HIV integrase inhibitors. Part 1: 2-Hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores

Add time:07/30/2019    Source:sciencedirect.com

We present a novel series of HIV integrase inhibitors, showing IC50s ranging from 0.01 to over 370 μM in an enzymatic assay. Furthermore, pharmacophore modeling study for the inhibitors was carried out to elucidate the structure–activity relationships. Finally, we found a 3D-pharmacophore model, which is composed of a hydrophilic and a hydrophobic domain, providing valuable information for designing other novel types of integrase inhibitors.

We also recommend Trading Suppliers and Manufacturers of 2-IODO-ISONICOTINIC ACID METHYL ESTER (cas 134579-47-8). Pls Click Website Link as below: cas 134579-47-8 suppliers

Prev:A diastereoselective synthesis of boceprevir's gem-dimethyl bicyclic [3.1.0] proline intermediate from an insecticide ingredient cis-cypermethric acid
Next:RGDS and DGEA (cas 134580-64-6)-induced [Ca2+]i signalling in human dermal fibroblasts)