The competitive N1-, N2-, O- and C-methylation of 3-trifluoromethyl-1H-pyrazol-5-ol for synthesis of analgesic compounds

Add time:07/12/2019    Source:sciencedirect.com

We have found selective conditions for methylation of 3-trifluoromethyl-1H-pyrazol-5-ol that allowed us to obtain mono-Me-substituted N1- and O-isomers as well N1,N2-, N1,O- and N2,O-disubstituted isomers. A tautomeric structure of the parent pyrazole and its Me-substituted derivatives was investigated using quantum-chemical calculations, X-ray diffraction analysis, IR and NMR spectroscopy. Besides, the quantum-chemical calculations were used to explain the methylation direction. An analgesic activity and acute toxicity of some synthesized compounds were evaluated in vivo experiments.

We also recommend Trading Suppliers and Manufacturers of 5-(trifluoroMethyl)-2-Thiophenecarboxylic acid (cas 128009-32-5). Pls Click Website Link as below: cas 128009-32-5 suppliers

Prev:Organocatalytic enantioselective sulfa-Michael addition of thiocarboxylic acids to β-trifluoromethyl-α,β-unsaturated ketones for the construction of stereogenic carbon center bearing a sulfur atom and a trifluoromethyl group
Next:Hydration of polyethylene glycol monododecyl ethers (C12Ei, for i = 6 and 10) in their diluted aqueous solutions)