Iodine-mediated direct synthesis of multifunctional 2-aminobenzimidazoles from N-substituted o-diaminoarenes and isothiocyanates

Add time:07/30/2019    Source:sciencedirect.com

Multifunctional 2-aminobenzimidazoles were directly synthesized through sequential addition of N-substituted o-diaminoarenes to isothiocyanates, formation of carbodiimides via I2-mediated oxidative desulfurization, and intramolecular cycloaddition. This efficient and eco-friendly synthetic process provides a facile access to diverse 2-aminobenzimidazole derivatives from readily accessible substrates under mild reaction conditions in a scalable fashion.

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