hemoglobin Columbia Missouri (cas 134604-90-3) or α2[88 (F9) Ala→Val]β2: A New High-Oxygen-Affinity Hemoglobin That Causes Erythrocytosis

Add time:07/30/2019    Source:sciencedirect.com

A previously undescribed hemoglobin variant, hemoglobin Columbia Missouri (cas 134604-90-3), α88 (F9) Ala→Val, was detected in a 22-year-old white man who was undergoing assessment for erythrocytosis. This new hemoglobin variant does not separate from hemoglobin A by electrophoresis in conventional media, by isoelectric focusing, or by electrophoresis of purified globin chains in 8 M urea. It exhibits a high oxygen affinity, with a P50 (oxygen tension at 50% saturation) of 19.3 torr for the patient's whole blood. The substitution of hemoglobin Columbia Missouri is an internal residue near the end of the F helix of the α chain. Hemoglobin Okazaki has an arginyl residue substitution for a cysteinyl residue at F9 (β93) in the β chain. In comparison with hemoglobin Okazaki, the substitution in hemoglobin Columbia Missouri has a more pronounced effect on oxygen affinity. Consequently, hemoglobin Columbia Missouri is associated with erythrocytosis, whereas hemoglobin Okazaki is not.

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