Anticancer effects of one-pot synthesized biogenic gold nanoparticles (Mc-AuNps) against laryngeal carcinoma

Add time:07/30/2019    Source:sciencedirect.com

Laryngeal carcinoma is the second commonest and most aggressive cancer originating in the squamous cells of the laryngeal epithelium. Undesirable complications and resistance to chemotherapy are the common problems which necessitate the development of alternative anticancer agents for the management of laryngocarcinoma. We herein report the biosynthesis of gold nanoparticles using Muntingia calabura (Mc-AuNps) and their anticancer efficacy against Hep2 cells line.The biologically synthesized gold nanoparticles were characterized by UV–visible spectroscopy, dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) study. The Mc-AuNps exhibited excellent monodispersity with an average diameter of 27 nm, with the negative zeta potential of about −18 mV as well as long-term stability.Our results showed that Mc-AuNps induced cytotoxicity in Hep2 cells and inhibited the cell proliferation by inducing apoptosis. Further study revealed that Mc-AuNps-induced apoptosis in Hep2 cells was associated with disruption of cell membrane, alteration of nuclear morphology and cell cycle arrest at G2 phase. These results clearly suggested that the green synthesis of Mc-AuNps could be used to treat laryngeal cancer cells.

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