Novel angucycline compound with both antigastrin (cas 10400-14-3)- and gastric mucosal protective-activities

Add time:07/31/2019    Source:sciencedirect.com

An angucycline series compound P371 A1 (1) from Streptomyces sp. P371 was established to have a novel structure comprising an ureido group at one of four sugar units on the basis of 2D NMR techniques. 1 exhibited an inhibitory activity against the pentagastrin-stimulated acid secretion as well as protective acitvities against HCl/ethanol- and indomethacin-induced gastric lesions.

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