Synthesis of a new glycosphingolipid, neurosporaside, from Neurospora crassa

Add time:08/01/2019    Source:sciencedirect.com

The glycosphingolipid neurosporaside (α-d-Glcp-(1→2)-β-d-Galp-(1→6)-β-d-Galp-(1→6)-β-d-Galp-(1→)-Cer) occurs in Neurospora crassa. We attempted to synthesize neurosporaside by block synthesis (route A) and linear synthesis (route B). Oligosaccharide derivatives were synthesized using trimethylsilyltrifluoromethanesulfonate and N-iodosuccinimide/trifluoromethane sulfonic acid as promoters. The target tetrasaccharide could not be attained via route A, but route B showed potential: glycosidic bonds (β-d-Galp-(1→6)-β-d-Galp-(1→6)-β-d-Galp) were formed stereoselectively, leading to the synthesis of glycosphingolipid 2.

We also recommend Trading Suppliers and Manufacturers of F-9 glycosphingolipid (cas 134711-49-2). Pls Click Website Link as below: cas 134711-49-2 suppliers

Prev:High-sensitivity quantification of glycosphingolipid glycans by ESI-MS utilizing ozonolysis-based release and isotopic Girard's reagent labeling
Next:Excessive interferon-α signaling in autoimmunity alters glycosphingolipid processing in B cells)