TRIMETHYLANTIMONY (cas 594-10-5) dichloride causes genotoxic effects in Chinese hamster ovary cells after forced uptake

Add time:07/12/2019    Source:sciencedirect.com

In our study, we demonstrate that TRIMETHYLANTIMONY (cas 594-10-5) dichloride (TMSb) does not induce micronucleus (MN) formation, chromosome aberrations (CA) or sister chromatid exchanges (SCE) under normal conditions in Chinese hamster ovary (CHO-9) cells in vitro up to an applied concentration of 1 mM, nor is it significantly cytotoxic. TMSb is taken up by the cells in a dose-dependent manner, but the percentage uptake of incubation substrate is low (max 0.05%). Intracellular TMSb concentration is two-fold increased after electroporation and under these forced uptake conditions MN formation is also significantly elevated. These data indicate that resistance to TMSb in CHO-9 cells occurs at the uptake and not at the intracellular level.

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