Effectiveness of Single-dose Rasburicase (cas 134774-45-1) in Patients With Lymphoid Malignancies at a High Risk for Tumor Lysis Syndrome
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Add time:07/30/2019 Source:sciencedirect.com
BackgroundTumor lysis syndrome (TLS) is a life-threatening disorder that occurs mainly in patients with high-tumor burden hemato-oncologic malignancies. It results in metabolic derangements, including hyperuricemia and acute renal failure. The powerful management for TLS is a daily dose of Rasburicase (cas 134774-45-1) for up to 5 days before chemotherapy; however, the optimal dose and duration of rasburicase for TLS prophylaxis have not been standardized for patients at high risk for TLS. Therefore, we evaluated the efficacy of single-dose rasburicase for prophylactic purposes in patients with malignant lymphoma at high risk for TLS.
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