One-pot synthesis of 4-aminated pyrrolo[2,3-d]pyrimidines from alkynylpyrimidines under metal-catalyst-free conditions

Add time:07/31/2019    Source:sciencedirect.com

A novel, general, and efficient one-pot sequential reaction toward a variety of 4-aminated-6-arylpyrrolo[2,3-d]pyrimidines from 5-alkynylpyrimidines has been developed. Microwave-assisted metal-free intramolecular cyclization and amination provided moderate to excellent yields of 4-aminated pyrrolo[2,3-d]pyrimidines in short reaction times. This method avoids the use of metal-catalyst and expensive additives and was shown to tolerate amines and anilines.

We also recommend Trading Suppliers and Manufacturers of 4-[(4-aminophenyl)methyl]-2-chloroaniline (cas 10414-75-2). Pls Click Website Link as below: cas 10414-75-2 suppliers

Prev:Synthesis of ring-halogenated histidines and histamines
Next:Experimental and computational evidence for hydrogen bonding interaction between 2′-deoxyadenosine conjugate adduct and amino-terminated organic film on Si(001))