Pyrrolidine-HOBt: an oxytriazole catalyst for the enantioselective Michael addition of cyclohexanone to nitroolefins in water

Add time:07/31/2019    Source:sciencedirect.com

A new analogue of the proline derived organocatalyst ‘pyrrolidine-HOBt’ has been designed and synthesized from l-prolinol and hydroxybenzotriazole (HOBt) employing a simple reaction protocol. The catalyst was found to be effective in promoting the asymmetric Michael addition of cyclohexanone to nitroolefins using water as the reaction medium. The reaction products γ-nitrocarbonyls are obtained in good yields and stereoselectivities.

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