Synthesis and antidiabetic activity of β-acetamido ketones
-
Add time:08/03/2019 Source:sciencedirect.com
This paper reports the use of trifluoroacetic acid as a catalyst in the Dakin–West reaction for the synthesis of β-acetamido ketones. The method has several advantages such as requiring only mild conditions and a low concentration of catalyst. Screening of 19 β-acetamido ketones for antidiabetic activity in vitro showed that their activity as peroxisome proliferator-activated receptor (PPAR) agonists and as dipeptidyl peptidase 4 (DPP-IV) inhibitors was fairly weak.
We also recommend Trading Suppliers and Manufacturers of 9-(acetamido)-5-aminobenzo[a]phenoxazin-7-ium chloride (cas 10430-46-3). Pls Click Website Link as below: cas 10430-46-3 suppliers
Prev:SnCl2·2H2O-catalyzed efficient synthesis of β-acetamido ketones and β-acetamido ketoesters under solvent-free conditions
Next:One-Pot Four-Component Dakin-West Synthesis of β-Acetamido Ketones Catalyzed by a Vanadium-Substituted Heteropolyacid) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Iron(III) chloride-catalyzed convenient one-pot synthesis of β-acetamido carbonyl compounds08/08/2019
- Design, synthesis and insecticidal activities of novel acetamido derivatives containing N-pyridylpyrazole carboxamides08/07/2019
- 5-Acetamido-3,5-dideoxy-L-glycero-L-manno-non-2-ulosonic acid-containing O-polysaccharide from marine bacterium Pseudomonas glareae KMM 9500T08/06/2019
- The impact of chloride or bromide ions on the advanced oxidation of atrazine by combined electrolysis and ozonation08/05/2019
- One-Pot Four-Component Dakin-West Synthesis of β-Acetamido Ketones Catalyzed by a Vanadium-Substituted Heteropolyacid08/04/2019
- SnCl2·2H2O-catalyzed efficient synthesis of β-acetamido ketones and β-acetamido ketoesters under solvent-free conditions08/02/2019
- Synthesis of 2,5-diformylfuran from 5-hydroxymethylfurfural in ethyl acetate using 4-acetamido-TEMPO as a recyclable catalyst08/01/2019
- Enhanced urease inhibition activity of Ag nanomaterials capped with N-substituted methyl 5-acetamido-β-resorcylate07/31/2019
