Aqueous electrospinning of poly(2-Ethyl-2-oxazoline (cas 10431-98-8)): Mapping the parameter space

Add time:08/03/2019    Source:sciencedirect.com

Recently, poly(2-oxazoline)s have regained significant interest and research has especially been focusing on biomedical applications. As non-woven nanofibrous mats show appealing features in this respect, the potential and limitations of electrospinning aqueous solutions of poly(2-ethyl-2-oxazoline) (PEtOx), the only poly(2-oxazoline) produced on industrial scale (i.e. Aquazol®) so far, was evaluated. The polymer molecular weight appeared to be the dominant factor defining the optimal concentration range for successful nanofiber production. The molar mass distribution, i.e. the dispersity (Ð), is relevant as well. However, it is not a limiting factor as defined PEtOx (Р< 1.2) could be electrospun without major adaptations to the electrospinning procedure that was optimized for the commercial grades of Aquazol® with Ð of 3–4. By varying the PEtOx molecular weight and concentration, a broad range of fiber diameters can be targeted. Furthermore, we demonstrated the transferability of the PEtOx electrospinning parameters and the reproducibility of the resulting fiber diameters by repeating the experiments on an independent mononozzle electrospinning device, by a different operator. In order to fulfil all prerequisites for industrialization, we also demonstrated the feasibility for upscaling the PEtOx nanofiber production process using a pilot scale multinozzle electrospinning set-up.

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