Four new cinnamoyl-phloroglucinols from the leaves of Xanthostemon chrysanthus

Add time:08/02/2019    Source:sciencedirect.com

Four new cinnamoyl-phloroglucinols (1–4) were isolated from the leaves of Xanthostemon chrysanthus. Compounds 1 and 2 represent the first example of natural phloroglucinols with an oxazole unit. Their structures were elucidated on the basis of NMR spectroscopic data and single crystal X-ray diffraction. Compound 3 showed moderate cytotoxic activity against MDA-MB-231 and SGC-7901 cells with IC50 values of 25.26 ± 0.35 μM and 31.2 ± 0.94 μM, respectively.

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