Short-step synthesis of naproxen. Regioselective Friedel-Crafts reaction of 2-chloro-2-alkylthio-propionates

Add time:07/31/2019    Source:sciencedirect.com

2-(6-Methoxy-2-naphthyl)propionic acid (4), dl-naproxen, was conveniently prepared by the regioselective reaction of alkyl 2-chloro-2-alkylthio-propionate (2) and 2-methoxynaphthalene (1) in good yield. This Friedel-Crafts reaction was found to be applicable to the other electron-rich aromatics.

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