Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors [1]

Add time:08/01/2019    Source:sciencedirect.com

The activity of a series of imidazo[2,1-b]thiazole guanylhydrazones as inhibitors of p90 ribosomal S6 kinase 2 (RSK2) is described. It was found that a small subset of compounds show both potent inhibition of RSK2 kinase activity and tumor cell growth in vitro. Detailed study of one of the most active compounds indicates a high degree of selectivity for inhibition of RSK2 compared to a spectrum of other related kinases. Selective inhibition of the MCF-7 breast tumor cell line compared to MCF-10A non-transformed cells, as well as selective inhibition of the biomarker GSK3 provides evidence that the compounds can affect the RSK2 target in cells.

We also recommend Trading Suppliers and Manufacturers of 5-nitro-6-(4-nitrophenyl)imidazo(2,1-b)thiazole (cas 106636-48-0). Pls Click Website Link as below: cas 106636-48-0 suppliers

Prev:Imidazo[2,1-b]thiazole derivatives as new inhibitors of 15-lipoxygenase
Next:Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds)