Aggregate formation in the intercalation of long-chain fatty acid esters into liposomes

Add time:08/01/2019    Source:sciencedirect.com

Various hydrophobic benzenediacetic esters, the corresponding benzenedipropionic esters, and branched alkyl esters were intercalated into DMPC liposomes, where the molar ratio (n/n) of ester:DMPC was 1:5. In the case of the very long-chain derivatives, double carbonyl peaks were observed in the 13C NMR spectrum. This doubling phenomenon was observed only for the carbonyl peaks, whose chemical shift is most sensitive to solvent polarity, and disappeared when the ester:DMPC molar ratio drops below 1:15. This doubling reflects the presence of two populations in these samples: one group includes those molecules which are intercalated within the liposome and feel the polarity corresponding to the liposomal microenvironment; the other consists of aggregates of these long-chain derivatives located in the extra-liposomal aqueous phase.

We also recommend Trading Suppliers and Manufacturers of Fatty acids, (C=14~18) and (C=16~22)-unsatd., 2-octyldodecyl esters (cas 132208-25-4). Pls Click Website Link as below: cas 132208-25-4 suppliers

Prev:Development and validation of a reversed-phase ion-pair liquid chromatography method for the determination of magnesium ascorbyl phosphate and melatonin in cosmetic creams
Next:Occurrence of perfluorinated carboxylic acids (PFCAs) in personal care products and compounding agents)