Decreased utilization of [2-14C]orotic acid for the synthesis of cytidine nucleotides in rat liver after administration of α-hexachlorocyclohexane

Add time:08/01/2019    Source:sciencedirect.com

Administration of α-1,2,3,4,5,6-hexachlorocyclohexane (α-HCH) to rats decreased the utilization of [2-14C]orotic acid for the synthesis of liver cytidine nucleotides. The specific radioactivities of uridine components of the acid-soluble pool and rRNA increased during the first hours of treatment with the drug. Later on the specific radioactivities of uridine nucleotides remained unchanged, while those of cytidine components decreased gradually. Administration of hydrocortisone increased the incorporation of labelled orotic acid into rRNA cytidylic acid.

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