Organotin esterification of (E)-3-(3-fluoro-phenyl)-2-(4-chlorophenyl)-2-propenoic acid: synthesis, spectroscopic characterization and in vitro biological activities. Crystal structure of [Ph3Sn(OC(O)C(4-ClC6H4) = CH(3-FC6H4))]

Add time:08/01/2019    Source:sciencedirect.com

Nine organotin esters, Me2SnL2 1, Me3SnL 2, n-Bu2SnL2 3, n-Bu3SnL 4, Ph3SnL 5, (PhCH2)2SnL2 6, [(Me2SnL)2O]2 7, Et2SnL2 8 and n-Oct2SnL2 9, of (E)-3-(3-fluorophenyl)-2-(4-chlorophenyl)-2-propenoic acid, HL have been synthesized and characterized by elemental analysis, IR, Multinuclear NMR (1H, 13C and 119Sn) and mass spectrometry. The geometry around the tin atom has been deduced and compared both in solution and solid states. The crystal structure of compound 5 has been determined by X-ray single crystal analysis, which shows a tetrahedral geometry around the tin atom with space group P1¯. These compounds have also been screened for bactericidal, fungicidal activities and cytotoxicity data.

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