N-hydroxyphenacetin (cas 19315-64-1) as a precursor of 3-subst1tuted 4-hydroxyacetanilide metabolites of phenacetin

Add time:08/03/2019    Source:sciencedirect.com

N-Hydroxyphenacetin on acid treatment or after N-ester formation will react with methionine viaN-acetyl-p-benzoquinoneimine (VI) to give 4-hydroxy-3-methyl-thioacetanilide, a new urinary metabolite of phenacetin.

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