Efficient and facile strategy to substituted 2-aminothiazoles via ring opening of α-nitroepoxides

Add time:08/03/2019    Source:sciencedirect.com

A novel and efficient reaction has been developed to synthesize a set of substituted 2-aminothiazoles from α-nitroepoxides and ammonium thiocyanate. This reaction could proceed smoothly at mild condition, to afford products for a wide range of substrates with good to excellent yields. A possible mechanism has also been proposed.

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