Antioxidative properties of a newly synthesized 2-glucosamine-thiazolidine-4(R)-carboxylic acid (GlcNH2Cys) in mice

Add time:08/03/2019    Source:sciencedirect.com

A new 2-substituted thiazolidine-4(R)-carboxylic acid (TCA), 2-glucosamine-TCA (GlcNH2Cys), was synthesized with its antioxidative properties, compared with those of 2 other 2-substituted TCAs, 2-gluco-TCA and 2-galacto-TCA. The GlcNH2Cys showed antioxidative properties of scavenging reactive free radicals (hydroxyl radical and superoxide anion), preventing macromolecules damage (deoxyribose, protein, and lipid), and was hepatoprotective against acetaminophen-induced liver damage by replenishing sulfhydryl levels, increasing the total antioxidative capacity of the liver, and inhibiting lipid peroxidation. GlcNH2Cys is a promising compound to protect against oxidative stress xenobiotics.

We also recommend Trading Suppliers and Manufacturers of THIAZOLIDINE-2-CARBOXYLIC ACID (cas 16310-13-7). Pls Click Website Link as below: cas 16310-13-7 suppliers

Prev:Design, synthesis and biological evaluation of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors
Next:Characterization of a novel tyrosinase inhibitor, (2RS,4R)-2-(2,4-dihydroxyphenyl)thiazolidine-4-carboxylic acid (MHY384))