Anticonvulsant activity of ester- and amide-type lipid conjugates of glycine and N-benzyloxycarbonylglycine

Add time:08/03/2019    Source:sciencedirect.com

The anticonvulsant activity of ester- and amide-type lipid conjugates of glycine and N-benzyloxycarbonylglycine (Z-glycine) was evaluated in the maximal electroshock (MES) test and the strychnine test. Regardless of the type of the conjugates the Z-glycine derivatives were always more potent than the corresponding glycine derivatives. The amide lipids proved to be more active than the ester derivatives. While the lipid carriers with straight chain fatty acids that did not contain glycine or Z-glycine did not show anticonvulsant activity in either of the tests applied, lipid carriers containing aromatic or aliphatic rings in the acids displayed activity although lower than the conjugates containing glycine or Z-glycine. The lipid conjugates did not display significant binding to the strychnine-sensitive glycine receptor or to the strychnine-insensitive NMDA receptor.

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