First practical resolution of a 3-(4-methoxyphenyl)glycidic acid ester by preferential crystallization and synthesis of diltiazem

Add time:08/03/2019    Source:sciencedirect.com

Among the various esters of 3-(4-methoxyphenyl)glycidic acid, 4-chloro-3-methylphenyl ester (±)-3 was found to exist as a conglomerate, and could be alternately resolved into (+)- and (−)-3 of >98% ee by a preferential crystallization procedure. Furthermore, a 1,5-benzothiazepine derivative, (+)-6, a significant intermediate of diltiazem, was prepared in one pot in 76% overall yield through the treatment of enantiomerically pure (−)-3 with 2-aminothiophenol followed by a ring closing reaction.

We also recommend Trading Suppliers and Manufacturers of 3-(3-METHOXYPHENYL)PROPIONIC ACID (cas 10516-71-9). Pls Click Website Link as below: cas 10516-71-9 suppliers

Prev:Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase
Next:Biodegradation of 4-chloroindole by Exiguobacterium sp. PMA)