Studies on uremic toxins; Structure-activity correlation in H-Asp(Gly)-OH

Add time:08/02/2019    Source:sciencedirect.com

The discovery of dipeptide, H-Asp(Gly)-OH, having an inhibition activity of PHA-induced lymphocyte transformation is reported. The seven analogs of H-Asp(Gly)-OH are described in which H-β-aspartyl, H-D-β-aspartyl, and Z-β-aspartyl respectively. The H-Gly-OH residue of H-Asp(Gly)-OH is also substituted for H-Sar-OH, H-β-Ala-OH, and H-Gly-OMe respectively. The biological activity of the seven analogs is compared with that of H-Asp(Gly)-OH on a PHA-induced lymphocyte transformation.

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