Synthesis of 1-aroyl(1-arylsulfonyl)-4-bis(trifluoromethyl)alkyl semicarbazides as potential physiologically active compounds

Add time:08/03/2019    Source:sciencedirect.com

1,1-Bis(trifluoromethyl)alkyl isocyanates obtained from perfluoroisobutene (PFIB) react with aroyl(arylsulfonyl)hydrazines. Twenty eight prospective biologically active polyfluorinated 1,4-substituted semicarbazides were synthesized. The structure of each new product was confirmed by analytical and spectroscopic methods. The Lipinski's and Gelovani's parameters were then calculated. Two adjustments to the Lipinski rules of five are suggested for fluorinated drug candidates.

We also recommend Trading Suppliers and Manufacturers of 4-(4-isopropylphenyl)butan-2-one (cas 10528-64-0). Pls Click Website Link as below: cas 10528-64-0 suppliers

Prev:Antihelminthic activity of some newly synthesized 5(6)-(un)substituted-1H-benzimidazol-2-ylthioacetylpiperazine derivatives
Next:vitamin D3 sulfoconjugate (cas 10529-43-8) in pregnant and lactating mother rats after dosing with 3H vitamin D3)