Regiospecific synthesis of 15-(4-[123I]iodophenyl)pentadecanoic acid-IPPA via methyl 15-(4-trimethylstannylphenyl)pentadecanoate

Add time:07/11/2019    Source:sciencedirect.com

The synthesis of methyl 15-(4-trimethylstannylphenyl)pentadecanoate (p-SnPPA), a precursor for the regiospecific production of 15-(4-[123I]-iodophenyl)pentadecanoic acid, is described. The stannylated precursor is synthesized in six steps from 4-bromophenylacetylene in an overall yield of 16%. p-SnPPA reacts with N.C.A. [123I]NaI in the presence of peracetic acid to yield IPPA in 62% radiochemical yield following hydrolysis.

We also recommend Trading Suppliers and Manufacturers of 15-(4-bromophenyl)pentadecanoic acid (cas 80503-45-3). Pls Click Website Link as below: cas 80503-45-3 suppliers

Prev:Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial
Next:Radioiodinated p-phenylene bridged fatty acids as new myocardial imaging agents: Syntheses and biodistribution in rats)