Asymmetric synthesis of phosphonic acid analogues for acylcarnitine

Add time:08/03/2019    Source:sciencedirect.com

Phosphonic acid analogues of acylcarnitine were prepared in an optically active form expecting CPT I inhibitory activities. The synthetic methodology was based on catalytic asymmetric dihydroxylation of β,γ-unsaturated phosphonates and subsequent regioselective amination via the cyclic sulfates.

We also recommend Trading Suppliers and Manufacturers of (4-dimethylamino-1-hydroxy-1-phosphono-butyl)phosphonic acid (cas 104361-73-1). Pls Click Website Link as below: cas 104361-73-1 suppliers

Prev:A site selective functionalisation of 1,3-bis(trifluoromethyl)benzene
Next:Novel quinolinone-phosphonic acid AMPA antagonists devoid of nephrotoxicity)